Putting All the Pieces Together For a Complete Seizure Preparedness Plan

Why do patients need a Seizure Preparedness Plan?

Minutes are precious—DIASTAT AcuDial works quickly

DIASTAT AcuDial can help complete your patients' plan

Why do patients need a Seizure Preparedness Plan?
  • More than 30% of all seizures are not controlled by antiepileptic drugs (AEDs) alone1
  • Prolonged or repetitive seizures may cause neuronal damage2
  • The longer a seizure lasts, the less likely it is to stop spontaneously and the more likely the next seizure will be prolonged3
  • When seizures persist untreated, significant mortality and morbidity may result.4


  • In another study, by Jordon KG, it was found that on average it took 85 minutes from emergency medical services (EMS) notification to the initiation of a treatment protocol.l6

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Minutes are precious during a seizure—DIASTAT AcuDial works quickly7
  • Rapid onset of action—begins working within 15 minutes8


* This study was conducted with diazepam solution, not diazepam gel.
  • Significantly faster than intramuscular (IM) injection, tablet, and suppository9
  • Rectal administration allows for rapid absorption9
  • The earlier treatment starts, the sooner seizures terminate.4

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DIASTAT AcuDial can help complete your patients' plan
  • In a pivotal study, no patients required emergency medical care10
  • DIASTAT AcuDial locks in the precise dose for accurate administration during a seizure7
  • Easy-to-use pre-measured doses for adults and children over 2 years,7 with no special handling instructions and a 4-year shelf life.12

Help your patients create a personalized Seizure Preparedness Plan now

Prepare a plan for a child/teen
Prepare a plan for an adult

References:
  1. Kwan P, Brodie MJ.Early identification of refractory epilepsy. N Engl J Med. 2000;342:314-319.
  2. DeGiorgio CM,Heck CN,Rabinowicz AL,Gott PS,Smith T,Correale J.Serum neuron-specific enolase in the major subtypes of status epilepticus.Neurology.1999;52:746-749.
  3. Shinnar S,Berg AT,Moshe SL, Shinnar R.How long do new-onset seizures in children last? Ann Neurol.2001;49:659-664.
  4. Working Group on Status Epilepticus.Treatment of convulsive status epilepticus: recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA.1993;270:854-859.
  5. Pellock JM,Marmarou A,DeLorenzo R.Time to treatment in prolonged seizure episodes. Epilepsy & Behav.2004;5:192-196.
  6. Jordan KG.Status epilepticus: a perspective from the neuroscience intensive care unit. Neurosurg Clin N Am.1994;5:671-686.
  7. DIASTAT AcuDial package insert. Aliso Viejo,Calif: Valeant Pharmaceuticals NA; Nov. 2006.
  8. Cloyd JC, Lalonde RL, Beniak TE,Novack GD.A single-blind,crossover comparison of the pharmacokinetics and cognitive effects of a new diazepam rectal gel with intravenous diazepam.Epilepsia. 1998;39:520-526.
  9. Moolenaar F,Bakker S,Visser J, Huizinga T.Biopharmaceutics of rectal administration of drugs in man IX.Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in man. Int J Pharmaceut.1980;5:127-137.
  10. Dreifuss FE,Rosman NP, Cloyd JC, et al. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med.1998;338:1869-1875.
  11. Data on file.Valeant Pharmaceuticals International.
 
IMPORTANT SAFETY INFORMATION

DIASTAT® AcuDial™ (diazepam rectal gel) is a gel formulation of diazepam intended for rectal administration in the management of selected, refractory patients with epilepsy, on stable regimens of AEDs, who require intermittent use of diazepam to control bouts of increased seizure activity for patients 2 years and older.

In clinical trials with DIASTAT®, the most frequent side effect was somnolence (23%). Less frequent adverse events reported were dizziness, headache, pain, vasodilation, diarrhea, ataxia, euphoria, incoordination, asthma, rash, abdominal pain, nervousness and rhinitis (1%-5%). Please see full DIASTAT AcuDial Prescribing Information.