Dosing and Administration of DIASTAT® AcuDial™ (diazepam rectal gel)>

IASTAT AcuDial is available in a twin pack configuration that you can prescribe in 2.5 mg increments. The pharmacist will dial, lock and set the syringes for your patients.

Update: 20 mg syringe has changed

Selecting the appropriate dose

Administration

Proper disposal

Dial & lock confirmation

Syringe inspection

Update: 20 mg syringe has changed

The 20mg DIASTAT AcuDial syringe has been modified for the sake of simplification and to minimize potential dosing errors:
  • The 20 mg syringe cannot be used for 10 mg doses
  • The minimum dose in the 20 mg syringe is 12.5 mg
  • Use the maximum dose (10 mg) on the 10 mg syringe to deliver a 10 mg dose to patients.

Important note: Even when the maximum dose is prescribed, both syringes must be dialed and locked before dispensing.

Important change: The available doses from the 10 mg syringe are 5, 7.5, and 10 mg. The available doses from the 20 mg syringe are 12.5, 15, 17.5, and 20 mg.

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Selecting the appropriate dose

In order to accurately prescribe DIASTAT AcuDial, the dose should be individualized for the maximum beneficial effect. The recommended dose has not changed and is still 0.2 — 0.5 mg/kg.



The following tables provide acceptable weight ranges for each dose and age category, such that patients will receive between 90% and 180% of the calculated recommended dose.

The safety of this strategy has been established in clinical trials.1



Print Dosing Recommendations Chart 
  • It is recommended that diazepam rectal gel be used to treat no more than five episodes per month and no more than one episode every five days.
  • Diazepam rectal gel is not recommended for chronic, daily use as an anticonvulsant because of the potential development of tolerance to diazepam.
  • Chronic daily use of diazepam may increase the frequency and/or severity of tonic clonic seizures, requiring an increase in the dosage of standard anticonvulsant medication. In such cases, abrupt withdrawal of chronic diazepam may also be associated with a temporary increase in the frequency and/or severity of seizures.

Please review and discuss the proper administration and disposal of DIASTAT AcuDial with your patients as well as how to inspect syringes to ensure tip is not cracked and proper dose has been dialed and locked.

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Administration of DIASTAT AcuDial

DIASTAT AcuDial should only be administered by caregivers who, in the opinion of the prescribing physician:
  • Can distinguish between a cluster of seizures and the patient's ordinary seizure pattern
  • Have been instructed on how to administer DIASTAT AcuDial and judged competent to do so
  • Understand explicitly which seizures may or may not be treated with DIASTAT AcuDial
  • Are able to monitor clinical response and recognize when the response mandates immediate professional medical evaluation.

Print complete Administration Instructions 

Watch Administration Instructions Video
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Proper Disposal of DIASTAT AcuDial

Patients should be instructed to discard any unused gel and NOT reuse syringes for any purpose.

Print complete Disposal Instructions 

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Dial and Lock Confirmation

DIASTAT® AcuDial™ (diazepam rectal gel) has a unique locking mechanism that ensures that your patients receive the correct dose. Remind your patients and their caregivers to inspect each DIASTAT AcuDial syringe BEFORE leaving the pharmacy.



Print complete Dial and Lock Instructions

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Syringe Inspection

Complaints of cracks at the base of the plastic tip have been received for both the 10 mg and 20 mg product twin-packs. We have not received any complaints on the 2.5 mg DIASTAT AcuDial (diazepam rectal gel) delivery system.

 

Print complete Syringe Inspection Instructions 

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